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How Does The Endocannabinoid System Work?

By MaryAnn Stanger ND  •  0 comments  •   9 minute read

Endocannabinoid system Diagram. What is the endocannabinoid system

You've probably heard about CBD and other compounds found in cannabis, but the system in your body that interacts with these substances might be new to you. This system is called the endocannabinoid system, or ECS for short. It's a complex network that plays a crucial role in keeping your body balanced and healthy overall.

Scientists are constantly learning more about the endocannabinoid system, and they're discovering that it affects many different parts of our health. This fascinating system is involved in a wide range of processes, from helping to manage your mood to controlling things like appetite and sleep patterns.

The goal of this guide is to help you understand the ECS better. We want to explain clearly how it works and how it relates to cannabinoids like CBD. Whether you're just starting to learn about this topic or you're looking to deepen your understanding, reading this blog will give you valuable information.

 

When Was The Endocannabinoid System Discovered?

The endocannabinoid system (ECS) is less known because it was recently discovered and remains under study. In the 1960s, Dr. Raphael Mechoulam isolated THC, allowing for detailed brain research. The first cannabinoid receptor was found in a rat's brain in 1988, suggesting the body also produces similar compounds. Further research identified more receptors.

The ECS was discovered through studying how cannabis affects the body. Its name reflects this, with "endo" meaning within and "cannabinoid" referring to cannabis compounds. The ECS involves natural cannabis-like molecules, their receptors, and the enzymes that manage them. Discovered in the late 20th century, the ECS is still being actively investigated for its role in health and balance.

 

Understanding The Endocannabinoid System

The ECS, popularly known as the ECS, is a complex cell-signaling system discovered between the late 1980s and early 1990s. Scientists discovered it by exploring tetrahydrocannabinol (THC), a well-understood and known cannabinoid from the cannabis plant.

Let's examine the word endocannabinoid. Endo is a short form for 'endogenous,' which is translated to means that it's produced naturally in your body. Cannabinoids are chemical compounds found in the cannabis plant.

Cannabinoids in the cannabis plant

There are over 100 known cannabinoids, including THC and cannabidiol (CBD). In other words, endocannabinoid refers to cannabis-like substances or compounds produced naturally inside your body.

This means that although often associated with cannabis, the ECS is available in your system even if you don't consume cannabis. We are still very far from fully understanding the ECS, but scientists suggest it might play a role in regulating vital body processes, including:

  • Mood
  • Sleep
  • Memory
  • Appetite
  • Immune System Response
  • Reproduction and Fertility, etc.

All these functions are linked to homeostasis, which will be our next topic of discussion.

 

Endocannabinoid System Functioning Role

The endocannabinoid system (ECS) is essential for keeping your body in a stable and balanced state, a condition scientists call homeostasis. Think of the ECS as your body's internal control center, constantly monitoring different processes to make sure everything stays within a healthy range.

This important regulatory system works hard to maintain your body's internal equilibrium, which is crucial for good health and overall well-being. When your body faces challenges, whether from illness, injury, or changes in things like temperature, the ECS kicks in to help.

Women using CBD to maintain a balanced Endocannabinoid system

The ECS uses a smart approach to deal with these disruptions. It releases special molecules called endocannabinoids, which act like natural messengers within your body. These cannabinoids then connect with specific protein-coupled receptors located throughout your body.

These receptors are like docking stations on the surface of cells. When an endocannabinoid binds to one of these protein-coupled receptors, it triggers a series of responses within the cell to help restore balance.

From helping to manage feelings of discomfort to regulating your mood and appetite, the ECS plays a key role in many different bodily functions. By coordinating these responses, the ECS helps your body stay healthy and able to bounce back from challenges.

 

How Does the Endocannabinoid System Work?

The ECS comprises three components: endocannabinoids, receptors, and enzymes. Stay with us as we examine the ECS in more detail.

Endocannabinoids

Endocannabinoids, also referred to as endogenous cannabinoids, are cannabinoid-like molecules produced by the human body. They include anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Endocannabinoids help maintain the body's internal environment and are produced as needed.

Endocannabinoid Receptors

Endocannabinoid receptors are found on the surface of your body cells. They detect changes in the body and communicate with the cells, prompting them to take action. In short, they help maintain homeostasis by monitoring what's happening in our bodies. They are the same components that bind to cannabinoid receptors.

Scientists have discovered two primary endocannabinoid receptors.

  • CB1 receptors
  • CB2 receptors

Both CB1 and CB2 receptors can be found throughout the body. However, CB2 receptors are more abundant in the immune system, tissues, and organs. CB1 receptors, on the other hand, are more concentrated in the brain and the central nervous system.

cannabinoid receptors

The endocannabinoids can bind to either receptor. The effects will be determined by the receptor's location and the endocannabinoid it binds to. For instance, endocannabinoids might bind to CB2 receptors in the immune cells, signaling inflammation in your body. 

Enzymes

Once the endocannabinoids have done their job, enzymes break them down. This prevents them from going overboard, which may upset the balance in the opposite direction.

Two main enzymes are known for this function:

  • FAAH - Associated with anandamide breakdown
  • MAGL - which breaks down 2-AG

The endocannabinoid system maintains homeostasis or balance in the internal environment using the three core components.

 

Synthetic Cannabinoids: A Risky Imitation

Synthetic cannabinoids are lab-created chemicals designed to mimic natural cannabis compounds like THC, but their structure differs. They are often much stronger than the side effects of THC, leading to unpredictable and dangerous effects such as severe anxiety, rapid heartbeat, and hallucinations.

Sold under names like "Spice" and "K2" with misleading labels, these substances pose serious health risks and are not a safe alternative to natural cannabis.

 

The Endocannabinoid System and CBD Working Together

The ECS and CBD (cannabidiol) form a dynamic partnership that has captured the attention of researchers and wellness enthusiasts alike.

CBD, a cannabinoid derived from the cannabis plant, interacts with the ECS's receptors, CB1 and CB2. CBD does not directly bind to them but acts as a barrier blocking signals. Many of these receptors are found in our vital organs and are shown in our endocannabinoid system diagram.

Instead, CBD influences these receptors by modulating their activity and enhancing the system's natural functions. In our diagram of the endocannabinoid system, you'll notice that these receptors also follow our central nervous system.

How The Endocannabinoid System Works In The Body

diagram endocannabinoid system

The interaction breaks down endocannabinoids, leading to increased levels of these compounds in the body. As a result, CBD's impact on the ECS is linked to various potential benefits. These benefits include managing discomfort, reducing swelling, promoting relaxation, and supporting overall balance.

This collaboration between CBD and the endocannabinoid system showcases the body's ability to harness external compounds. They offer a promising avenue for a holistic health approach.

 

How To Utilize CBD and The Endocannabinoid System

Choosing the right CBD oil is key when you're looking to use CBD to support your body's natural balance. Here's what you need to know:

  • Full-spectrum CBD: This type of CBD oil contains all the natural compounds in the hemp plant, including other cannabinoids like CBG and CBN. These extra cannabinoids can work with CBD to give you a wider range of benefits.
  • Broad-spectrum CBD: Similar to full-spectrum, but without the THC. This is a good choice if you want to avoid any trace of THC.
  • CBD isolate: This is pure CBD with no other cannabinoids. It's a good option if you want to try CBD on its own.

 

Different Cannabinoids, Different Benefits

While CBD has gained significant attention for its potential wellness properties, it's important to remember that cannabis contains many other beneficial compounds called cannabinoids. Each of these cannabinoids interacts with the body's endocannabinoid system in unique ways, potentially offering different advantages.

  • CBG (cannabigerol) is often referred to as the "stem cell" of cannabinoids because other cannabinoids originate from it. Research suggests CBG may have properties that could help reduce inflammation and alleviate pain.
  • CBN (cannabinol) is another cannabinoid that has become known for its potentially relaxing effects, which may contribute to improved sleep quality.
  • CBC (cannabichromene) is being studied for its potential to support skin health and overall well-being. Exploring these diverse cannabinoids could unlock a wider range of natural health solutions.

 

Using CBD for Specific Goals

If you have a particular health goal you're aiming for, you might want to consider using a CBD product that also contains other specific cannabinoids. These combinations can potentially enhance the overall effects.

  • Mood: For example, if your goal is to improve your mood, looking for a product that includes CBG or additional CBD might be beneficial due to their potential mood-regulating properties.
  • Better sleep: For those seeking better sleep, choosing a product with CBN alongside CBD could be helpful, as CBN is known for its relaxing qualities.
  • Discomfort: If you're looking to address discomfort, a product containing CBC in addition to CBD might be worth trying, as CBC has shown promise in this area.

Keep in mind that individual responses can vary, so finding the ideal CBD product and the right dosage for your specific needs may involve some personal experimentation. It's always wise to begin with a low dose and gradually increase it while observing how your body reacts.

 

Other Factors That Influence the Endocannabinoid System

Believe it or not, other factors, like cannabinoids, can influence the ECS. Your lifestyle can have a heavy impact on its effectiveness. Let's talk about them.

Influence of Diet, Exercise, and Stress

Lifestyle choices significantly affect the endocannabinoid system (ECS). A diet rich in omega-3 fatty acids, found in fatty fish, flaxseeds, and walnuts, supports endocannabinoid production. Regular exercise boosts ECS activity by releasing endocannabinoids, contributing to mood elevation like the "runner's high."

people working out under the influence of CBD

Conversely, chronic stress can disrupt the ECS by interfering with endocannabinoid production and receptor sensitivity, potentially leading to health issues. Stress management techniques such as meditation, yoga, and deep breathing can promote a healthier ECS.

Implications for Overall Well-being

The interplay between lifestyle factors and the ECS profoundly affects well-being. Cultivating healthy habits, managing stress, and maintaining a balanced diet can contribute to a properly functioning endocannabinoid system.

This shows how the body naturally seeks balance. What we do affects how well this system works to keep us healthy overall. The ECS can change based on what happens around us. This shows how our actions and this important body system work together.

Sum It Up!

What is the endocannabinoid system? The endocannabinoid system (ECS) is your body’s natural balance keeper. It helps regulate important things like mood, sleep, and how you feel pain.

Your body makes its cannabinoids to help the ECS do its job. Adding CBD gives the ECS a boost to better manage things like discomfort, mood, and sleep.

This can help your body stay balanced overall. Taking care of yourself, in addition to CBD, can help the ECS. Eating well, exercising, and managing stress can improve its effectiveness.

Why Should You Buy Zatural CBD?

Taking CBD will give your body the extra boost to keep your endocannabinoid system running at 100%. Our CBD comes from high-quality organic industrial hemp. Our product is just what your ECS needs to maintain homeostasis and overall well-being. Don't just take our word for it; give us a try today.

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For educational purposes only.

*FDA DISCLAIMER -These statements have not been evaluated by the FDA.

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