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How Does The Endocannabinoid System Work?

By MaryAnn Stanger ND  •  0 comments  •   7 minute read

Endocannabinoid system Diagram. What is the endocannabinoid system

You've likely heard of CBD and other cannabinoids, but the system that interacts with them might be less familiar. The endocannabinoid system (ECS) is a complex network within your body that plays a role in maintaining overall well-being.

Scientists continuously uncover new insights about the endocannabinoid system, revealing its influence on various aspects of our health. This remarkable system involves numerous bodily functions, from managing mood to regulating appetite and sleep.

This guide aims to help you understand the ECS. We hope to provide a clear understanding of how it works and its relationship to cannabinoids like CBD. Whether you're new to the topic or seeking to expand your knowledge, you'll gain valuable insights by reading this blog.

 

When Was The Endocannabinoid System Discovered?

Everyone has heard about the digestive and circulatory systems, but very few people know about the ECS. Why's that? The system was recently discovered and has remained understudied.

In the early 1960s, Dr. Raphael Mechoulam, an Israeli scientist, identified and isolated THC for the 1st time. Being able to isolate specific cannabinoids improved studies of the human brain.

In 1988, the first cannabinoid receptor was discovered in a rat's brain; more receptors were found as time passed. That's how the ECS was discovered. Its name comes from cannabis, the plant that led to its discovery.

 

Understanding The Endocannabinoid System

The ECS, popularly known as the ECS, is a complex cell-signaling system discovered between the late 1980s and early 1990s. Scientists discovered it by exploring tetrahydrocannabinol (THC), a well-understood and known cannabinoid from the cannabis plant.

Let's examine the word endocannabinoid. Endo is a short form for 'endogenous,' which is translated to mean that it's produced naturally in your body. Cannabinoids are chemical compounds found in the cannabis plant.

There are over 100 known cannabinoids, including THC and cannabidiol (CBD). In other words, endocannabinoid refers to cannabis-like substances or compounds produced naturally inside your body.

This means that although often associated with cannabis, the ECS is available in your system even if you don't consume cannabis.

We are still very far from fully understanding the ECS, but scientists suggest it might play a role in regulating vital body processes, including:

  • Mood
  • Sleep
  • Memory
  • Appetite
  • Immune System Response
  • Reproduction and Fertility, etc.

All these functions are linked to homeostasis, which will be our next topic of discussion.

 

The Endocannabinoid System: Its Role in Homeostasis

The endocannabinoid system plays a pivotal role in maintaining balance within the body, a state known as homeostasis. This important regulatory network acts as a control center, constantly monitoring various physiological processes and working to ensure they remain within a stable range.

 Women using CBD to maintain a balanced Endocannabinoid system

The endocannabinoid system (ECS) is a sophisticated regulatory network that tirelessly works to maintain the body’s internal balance or homeostasis.

This delicate equilibrium is essential for optimal health and well-being. When faced with internal or external stressors, such as illness, injury, or even fluctuations in temperature, the ECS springs into action.

The system employs a strategic approach to counteract these disturbances. It releases specialized molecules called endocannabinoids, which act as the body's natural messengers.

These endocannabinoids interact with specific receptor sites throughout the body, initiating a cascade of responses to restore balance. From managing discomfort to regulating mood and appetite, the ECS plays a pivotal role in numerous physiological processes. By orchestrating these responses, the ECS helps to maintain overall health and resilience.

 

How Does the Endocannabinoid System Work?

The endocannabinoid system comprises three components: endocannabinoids, receptors, and enzymes. Stay with us as we examine the ECS in more detail.

Endocannabinoids

Endocannabinoids, also referred to as endogenous cannabinoids, are cannabinoid-like molecules produced by the human body. They include anandamide (AEA) and 2-arachidonoylglycerol (2-AG). Endocannabinoids help maintain the body's internal environment and are produced as needed.

Endocannabinoid Receptors

Endocannabinoid receptors are found on the surface of your body cells. They detect changes in the body and communicate with the cells, prompting them to take action.

In short, they help maintain homeostasis by monitoring what's happening in our bodies. They are the same components that endocannabinoids and cannabinoids bind to.

Scientists have discovered two primary endocannabinoid receptors;

  • CB1 receptors
  • CB2 receptors

Both these receptors can be found throughout the body. However, CB2 receptors are more abundant in the immune system, tissues, and organs. CB1 receptors, on the other hand, are more concentrated in the brain and the central nervous system.

The endocannabinoids can bind to either receptor. The effects will be determined by the receptor's location and the endocannabinoid it binds to. For instance, endocannabinoids might bind to CB2 receptors in the immune cells, signaling inflammation in your body. 

Enzymes

Once the endocannabinoids have done their job, enzymes break them down. This prevents them from going overboard, which may upset the balance in the opposite direction.

Two main enzymes are known for this function:

  • FAAH - Associated with anandamide breakdown
  • MAGL - which breaks down 2-AG

The endocannabinoid system maintains homeostasis or balance in the internal environment using the three core components.

 

The Endocannabinoid System and CBD Working Together

The ECS and CBD (cannabidiol) form a dynamic partnership that has captured the attention of researchers and wellness enthusiasts alike.

CBD, a cannabinoid derived from the cannabis plant, interacts with the ECS's receptors, CB1 and CB2. CBD does not directly bind to them but acts as a barrier blocking signals. Many of these receptors are found in our vital organs and are shown in our endocannabinoid system diagram.

Instead, CBD influences these receptors by modulating their activity and enhancing the system's natural functions. In our diagram of the endocannabinoid system, you'll notice that these receptors also follow our central nervous system.

diagram endocannabinoid system

The interaction breaks down endocannabinoids, leading to increased levels of these compounds in the body. As a result, CBD's impact on the ECS is linked to various potential benefits. These benefits include managing discomfort, reducing swelling, promoting relaxation, and supporting overall balance.

This collaboration between CBD and the endocannabinoid system showcases the body's ability to harness external compounds. They offer a promising avenue for a holistic health approach.

 

How To Utilize CBD and The Endocannabinoid System

Choosing the right CBD oil is key when you're looking to use CBD to support your body's natural balance. Here's what you need to know:

  • Full-spectrum CBD: This type of CBD oil contains all the natural compounds in the hemp plant, including other cannabinoids like CBG and CBN. These extra cannabinoids can work with CBD to give you a wider range of benefits.
  • Broad-spectrum CBD: Similar to full-spectrum, but without the THC. This is a good choice if you want to avoid any trace of THC.
  • CBD isolate: This is pure CBD with no other cannabinoids. It's a good option if you want to try CBD on its own.

Different Cannabinoids, Different Benefits

While CBD is often in the spotlight, other cannabinoids can also be helpful.

Using CBD for Specific Goals

If you have a particular health goal in mind, consider using a CBD product with specific cannabinoids. For example:

Remember: Everyone is different, so finding the right CBD product and dosage for you might take some experimentation. Always start with a low dose and gradually increase it as needed. 

 

Other Factors That Influence the Endocannabinoid System

Believe it or not, other factors, like cannabinoids, can influence the ECS. Your lifestyle can have a heavy impact on its effectiveness. Let's talk about them.

Influence of Diet, Exercise, and Stress

Lifestyle choices significantly influence the endocannabinoid system (ECS). Nutrition plays a crucial role; a diet rich in omega-3 fatty acids in fatty fish, flaxseeds, and walnuts supports healthy ECS function. These fats are building blocks for endocannabinoids.

Regular physical activity also benefits the ECS. Exercise triggers the release of endocannabinoids, contributing to euphoria often described as a "runner's high." This suggests a link between exercise and the ECS's role in mood regulation.

On the other hand, chronic stress can disrupt the ECS. Stress hormones can interfere with endocannabinoid production and receptor sensitivity. This imbalance can contribute to various health issues. By managing stress through techniques like meditation, yoga, or deep breathing, you can promote a healthier ECS.

 

Implications for Overall Well-being

The interplay between lifestyle factors and the ECS profoundly affects well-being. Cultivating healthy habits, managing stress, and maintaining a balanced diet can contribute to a properly functioning endocannabinoid system.

This shows how the body naturally seeks balance. What we do affects how well this system works to keep us healthy overall. The ECS can change based on what happens around us. This shows how our actions and this important body system work together.

 

Sum It Up!

What is the endocannabinoid system? The endocannabinoid system (ECS) is your body’s natural balance keeper. It helps regulate important things like mood, sleep, and how you feel pain.

Your body makes its cannabinoids to help the ECS do its job. Adding CBD gives the ECS a boost to better manage things like discomfort, mood, and sleep.

This can help your body stay balanced overall. Taking care of yourself, in addition to CBD, can help the ECS. Eating well, exercising, and managing stress can improve its effectiveness.

 

Why Should You Buy Zatural CBD?

Taking CBD will give your body the extra boost to keep your endocannabinoid system running at 100%. Our CBD comes from high-quality organic industrial hemp. Our product is just what your ECS needs to maintain homeostasis and overall well-being. Don't just take our word for it; give us a try today.

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For educational purposes only.

*FDA DISCLAIMER -These statements have not been evaluated by the FDA.

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